Strains commonly chosen for physical discomfort and chronic pain.
50 strains
Cannabis has been used for pain for millennia, and modern research supports its role — particularly for chronic pain, where the endocannabinoid system modulates pain signaling. The best analgesic strains combine THC (for pain perception) with CBD and caryophyllene (for inflammation). The right strain depends on the type of pain: nerve pain responds differently than inflammatory or muscular pain.
Caryophyllene is the standout — it's the only terpene that directly activates CB2 receptors (like CBD), providing anti-inflammatory pain relief. Myrcene relaxes muscles. Humulene (hoppy) also has anti-inflammatory properties. A strain with caryophyllene + myrcene + humulene covers multiple pain pathways.
For acute flare-ups, inhalation (vaping at 185–200°C) provides rapid relief within minutes. For all-day chronic pain management, edibles or tinctures provide longer-lasting baseline coverage. Topicals (balms, patches) can target localized pain without psychoactive effects.