Cannabis contains over 100 cannabinoids — chemical compounds that interact with your body's endocannabinoid system. THC and CBD are the best-known, but emerging research on CBG, CBN, CBC, and THCV reveals a richer picture of how cannabis works.
The primary psychoactive compound. Binds to CB1 receptors producing euphoria, altered perception, appetite stimulation, and pain relief. Modern strains reach 25-35% THC. Therapeutic uses include chronic pain, nausea, appetite loss, and PTSD.
Strains high in THC: Most modern hybrids; strongest include Godfather OG, Bruce Banner, Ghost Train Haze
Non-psychoactive, counteracts THC-induced anxiety. Activates serotonin receptors for anti-anxiety effects, TRPV1 for pain relief. FDA-approved for epilepsy (Epidiolex). Used for anxiety, inflammation, pain, seizures, and sleep.
Strains high in CBD: Charlotte's Web, ACDC, Harlequin, Cannatonic, Ringo's Gift
The 'mother cannabinoid' — THC and CBD both derive from CBG. Non-psychoactive. Shows promise for glaucoma (reduces intraocular pressure), inflammatory bowel disease, and bacterial infections. Typically present in small amounts (<1%) in most strains.
Strains high in CBG: White CBG, Jack Frost CBG, Super Glue CBG (bred specifically for high CBG)
Forms when THC degrades over time (oxidation). Mildly psychoactive (~10% of THC's potency). Known for strong sedative effects — old, aged cannabis is naturally higher in CBN. Studied for sleep, pain relief, and appetite stimulation.
Strains high in CBN: Aged/oxidized flower of any strain; also selectively bred cultivars like CBN-rich indicas
Non-psychoactive, binds poorly to CB1 but strongly to TRPV1 and TRPA1 receptors. May enhance neurogenesis (brain cell growth) and has anti-inflammatory, analgesic, and anti-acne properties. Works synergistically with other cannabinoids.
Strains high in CBC: Landrace sativas, some high-CBD cultivars; often co-occurs with CBD
Psychoactive at high doses but often described as clear-headed and energetic. Acts as an appetite suppressant (unlike THC which stimulates appetite) and may help with diabetes by regulating blood sugar. More common in African sativa landraces.
Strains high in THCV: Durban Poison, Doug's Varin, Malawi Gold, Red Congolese